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Mining Edge Solutions;
Forging Breakthrough
Innovation

Advanced AI Innovation Partner for R&D & Commercial Breakthrough.

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> Novamine has solved novelty for A.I.

Novelty + Rigour Breakthrough

Novelty

Verifiably original concepts, free from safe precedents and prior art, generated from the uncharted regions of the data graph.

Rigour

Adversarial scrutiny in silico to surface only the most unique, scientifically defensible, and testable solutions.

Breakthrough

A set of catalytic insights and viable vectors to rapidly accelerate R&D on your most intractable challenges.

> Recombination isn't enough.

Statistical Gravity

LLMs are statistically derivative.

  • They gravitate toward the familiar, converging on solutions biased toward safe precedents, prior art and recombinant ideas.
  • This limitation is irreversibly baked into the intelligence itself. Their architecture operates within tight boundaries that force mode collapse - a structural failure where diverse, unconventional ideas are abandoned in favour of generic, average responses.
  • Training and alignment protocols like RLHF (human feedback), RLAIF (AI feedback), and Direct Preference Optimisation (paired preference datasets) narrow these boundaries further by anchoring outputs to existing human preferences and safety guidelines.

Multi-Agent Adversarial Network

Novamine is an R&D accelerator, driven by highly specialised, proprietary generators designed to shatter conventional consensus patterns.

By operating beyond standard architectural boundaries, this first stage intentionally maximises raw, unfiltered novelty; generating a vast landscape of radical concepts that ranges from highly viable vectors to unviable ideas.

To isolate the viable from the unviable, the system then ushers each candidate through a multi-agent crucible to stress-test, challenge, and eliminate hallucinations, false mechanisms, and inflated novelty, until only the most unique, scientifically defensible, and testable solutions remain.

Escape Velocity

Novamine is an AI R&D Augmentation Platform for deep scientific inquiry and complex problem resolution; moving beyond conventional analytics to transform difficult challenges into actionable, testable outcomes.

We exist to break your organisation out of the plateaux that stall critical projects, exploring thousands of hypotheses while simultaneously eliminating the dead ends responsible for months of misdirected R&D.

  • Guaranteed Outcome: Multiple entirely new, scientifically robust avenues of innovation for your team to explore.
  • The Target: A fully fledged breakthrough, complete with experimental design and a testable validation roadmap.

Human-in-the-Loop, by Design

Novamine bridges human ingenuity and computational power by augmenting expert assessment, not replacing it.

We radically stretch the search space, but hypotheses only become truly valuable when they are tested against human expertise, experimental reality, and commercial viability. This is why we work human-in-the-loop from concept to lab, transforming novel hypotheses into credible R&D programmes.

Every engagement is protected under a strict NDA, and your proprietary data is never retained or reused. Generated IP is either transferred exclusively to you or licensed on agreed terms.

> Case Studies

ALS / Motor Neurone Disease

A wet-lab-ready drug pairing for ALS

The Challenge

The Euan MacDonald Centre for Motor Neurone Disease Research at the University of Edinburgh, led by Dr Bhuvaneish Selvaraj, asked Novamine to identify pairs of drugs, drawn from libraries of compounds already studied or approved in humans, most likely to reverse the cellular damage behind the great majority of ALS cases. Constraints were strict: both drugs had to reach the brain at safe human doses, carry no overlapping serious side effects, and act through complementary biological routes. The output had to be a ranked shortlist a wet lab could actually run.

The Leap Novamine Made

Rather than treating the failing motor neuron as a single broken part to be fixed, the engine utilised closed-loop control principles to reframe the cell as a system trapped in a self-reinforcing feedback cycle; where any single intervention is quietly undone by the other half of the loop within hours. This led to a pairing strategy, largely absent from the repurposing literature, in which one drug restores the cell's internal organisation while the other removes the stress that would push it straight back into failure. Neither alone produces a durable result. Together they produce a rescue that holds.

Value to the Client

The output is a wet-lab-ready protocol that narrows thousands of compounds to a specific, defensible pair, complete with controls, timing, and pass/fail criteria. It compresses months of exploratory screening into a single targeted experiment, and carries clinical translation potential because both drugs already have human safety data. The pairing has been selected for funded laboratory trials at the Euan MacDonald Centre, now underway.

“

The Novamine system offers exciting potential not only to identify novel treatment targets and strategies, but also potential multi-drug/gene therapy approaches, where the therapeutic whole will be greater than the sum of the parts.
Dr Brian Dickie MBE

Chief Scientist, Motor Neurone Disease Association

Aerospace Engineering

Three routes to a slat-free wing

The Challenge

Design an airfoil for a very large, high-wing cargo aircraft cruising at Mach 0.6 on 1–2 hour missions, carrying heavy payloads in and out of short, unprepared dirt strips. The wing must deliver efficient transonic cruise and extreme short-takeoff-and-landing performance simultaneously, without the weight, cost, and failure modes of conventional multi-element high-lift systems.

The Leap Novamine Made

Rather than optimising a single airfoil concept, the engine produced a portfolio of fundamentally different attack angles on the same constraint set. The "Cuffed Super-GAW" utilised a principle from fighter-jet vortex management to create a fixed leading-edge geometry that lies dormant at cruise and activates automatically at high angles of attack, replacing mechanical complexity with aerodynamic state-switching. The 'Dragon-Edge' replaced the conventional smooth leading edge with an undulating, contoured profile that organises an array of stable streamwise vortices at high angles of attack — turning what would normally be wasted turbulent energy into useful lift. The cruise drag penalty is small and quantified; it is overwhelmed by the system-level weight savings of removing the entire slat apparatus. The 'Topologically Robust Airfoil' inverted the problem entirely: instead of pursuing a pristine laminar surface that degrades unpredictably on a dirt runway, it engineered a deliberately structured micro-topology - a surface whose roughness pattern is part of the design, not a defect to be minimised. Performance becomes radically insensitive to the real-world contamination that plagues conventional wings, because the wing is already operating in a regime that conventional wings only encounter once they are dirty. Each concept arrived at a simpler and more reliable wing, via a genuinely distinct engineering philosophy: state-switching geometry, vortex-recruitment lift, and designed-in robustness.

Value to the Client

Three independent, wind-tunnel-testable hypotheses delivered in a single engagement, each offering a credible path to eliminating mechanical high-lift systems and reducing lifecycle cost by an estimated 5–8%. The breadth of the portfolio gives the client parallel R&D options rather than a single bet.

“

Perfect for R&D. Cuff, whale fins, dragon edge, GENUINELY NEW. Actual technical solutions were highly plausible.
Clemmie Mitchell

Radia Inc., Aerospace Engineering

Calcium Carbonate Recovery · Avgo Biotech

Lifting calcium carbonate recovery to 93%, on a continuous three-field line.

The Challenge

Avgo Biotech's incumbent process settled calcium carbonate slurry overnight and ran a thermal soak to dry it. Recovery sat at around 80%, the line was expensive, and it demanded constant manual attention. The brief was tight: recover more than 90% in dried form, hold running cost below £10 per tonne, cap capital at £50,000 on off-the-shelf equipment, and make it a continuous, single-button line.

The Leap Novamine Made

Rather than optimising settling or drying in isolation, the engine treated the line as three coupled physical fields: centrifugal, electrokinetic, and thermodynamic - each held to its most efficient window. Unusually, it designed a feed-forward loop that ties cyclone apex behaviour to belt cake thickness, keeping the electro-osmotic step locked in the narrow 9–12 mm band where its water flux dominates vacuum - a coupling that doesn't appear in the existing dewatering literature. The result is a control architecture that turns three established unit operations into a single, continuous, self-regulating line.

Value to the Client

Recovery rises from 80% to 93%. A 12–16 hour batch becomes a continuous line measured in minutes. Energy holds at ≤20 kWh per tonne, OPEX comes in below £6 per tonne, and CAPEX lands at £49,000, inside the cap. Every component is off-the-shelf. One button starts it.

“

Novamine provided high-tech solutions and added value to Avgo's process problems. The output was outstanding.
Andrew Stacey

CEO, Avgo Biotech

ALS / Motor Neurone Disease · Euan MacDonald Centre

A novel biomarker index for diagnosing and tracking ALS

The Challenge

The Euan MacDonald Centre asked Novamine to identify novel biomarkers capable of diagnosing ALS, stratifying patients, and tracking disease progression; detectable in cerebrospinal fluid. The brief demanded patterns of markers rather than single molecules, prioritised signals originating from the brain and spinal cord, and required robustness against the real-world variability of clinical samples. Everything had to be grounded in known disease biology.

The Leap Novamine Made

Current diagnostic biomarkers measure how much of a molecule is present; a reading that shifts with lab conditions, sample handling, and batch-to-batch variation before the disease signal even enters the picture. The engine designed an index that reads unique differences between paired molecular signals rather than their absolute levels — a measurement strategy that is intrinsically robust to the lab and handling variation that distorts conventional readings. Unusually, the design includes a built-in self-test: deliberately break the mechanism, confirm that performance collapses, then restore it and recover; a form of engineered falsifiability that, to our knowledge, does not appear in the existing diagnostic literature for this disease.

Value to the Client

The output is a complete diagnostic architecture ready to take into the laboratory. It targets a substantial sensitivity uplift over current best-in-class approaches at the same clinical specificity. The proof-of-concept can run on existing sample banks, and the design is extensible to related conditions.

“

We are excited about the potential for the cutting-edge tech that Novamine brings to augmenting R&D, and the paths it might uncover.
Dr. Bhuvaneish T. Selvaraj

Senior Research Fellow, University of Edinburgh

Water Well Biocide Formulation · Pantonite

Eliminating biofilm without the foam - a kinetically-gated biocide protocol for well redevelopment.

The Challenge

Pantonite's well cleaning agent is used with aggressive agitation (jetting, surging, airlifting). It needed a biocide to kill the biofilms that choke water wells, but the only biocide available caused uncontrollable foaming the moment it was agitated. The brief was precise: find a biocide that is effective against well biofilms, stable in a highly acidic formulation, causes no foaming under agitation, and meets NSF/ANSI 60 certification for potable water.

The Leap Novamine Made

The obvious route is to screen low-foaming biocides for acid compatibility and pick the least bad compromise. The engine reframed the problem entirely: rather than searching for a chemical that avoids reacting with the acid, it designed a system where a deliberately reactive biocide is held in a stable 'loaded state' by the very acidity that should destroy it; then triggered to act only when diluted into the well environment. The chemical incompatibility that every formulator would treat as a dealbreaker becomes, unusually, the control mechanism itself.

Value to the Client

The output is a complete two-part protocol: formulation, tiered dosing strategy, field assessment procedure, active quenching step, and regulatory clearance criteria, ready for pilot trials. It replaces a single-ingredient substitution with an integrated chemical system that eliminates foaming, controls degradation by-products, and is designed to clear potable water standards within a defined flushing volume.

“

Novamine didn't just suggest an alternative ingredient, they redesigned how we thought about the problem. Their mechanism-first reasoning reframed our challenge from finding a compatible additive to designing a controlled chemical system.
Savas Danos

Pantonite, US Commercial Water Chemistry

Dental / Medical Device

A calculus softener that protects by design, not by dilution

The Challenge

The process for removing calculus (tartar) hasn't changed in decades. Hygienists spend time with ultrasonics and hand instruments, causing patient discomfort and operator fatigue. Existing chemical approaches that meaningfully soften calculus tend to etch enamel, irritate tissue, or require low pH, so clinicians default to brute mechanical force. The brief called for a near-neutral, 3–5 minute chairside pretreatment that halves scaling time without increasing sensitivity or damaging any surface in the mouth.

The Leap Novamine Made

The conventional approach to dissolving mineral deposits is to throw a powerful chelator at them and hope the collateral damage is acceptable. The engine reframed the selectivity problem: rather than limiting how much chemistry reaches the tooth, it limited how much chemistry the formulation is capable of delivering. The active agents arrive pre-loaded, their capacity to strip minerals deliberately capped before they ever contact a surface. The result is a system whose safety margin is not dependent on careful application technique or short dwell times, but is built into the molecular architecture of the gel itself. It can only take what the weakest structure in the mouth can afford to lose.

Value to the Client

A formulation concept with a clear, low-cost bench validation pathway and a commercially attractive unit cost, designed from the outset to satisfy the safety panel required for a device-route regulatory dossier. The pre-loaded safety logic gives the product a defensible differentiation that competitors cannot easily replicate by adjusting concentration or pH alone.

“

Calculus removal hasn't fundamentally changed in decades, it's still slow, uncomfortable and hard on the operator. When we saw a genuinely novel, near-neutral approach to softening it, the commercial case was obvious enough that we chose to partner on bringing it to market.
Jameel Gardee

Digital Dentist. Head of Education and Global Relationships, Avant Garde Dentistry

Goodness Pots · Children's Food Fortifier

An undetectable child nutrition fortification

The Challenge

Goodness Pots asked Novamine to develop a children's food-based nutrition powder, added by parents to everyday meals like porridge, yoghurt, smoothies & soups, that delivers meaningful micronutrient value while being completely undetectable to the child. The constraints were tight: at least 80% food-derived ingredients, no taste, no smell, no grit, no visible change in food, full spoon-dispersibility in both hot and cold matrices, 12–24 month shelf life, UK-manufacturable, and positioned as food, not supplement.

The Leap Novamine Made

Rather than adding more minerals on top of a diet that already contains them, the engine reframed the problem entirely: in cereal-heavy children's meals, phytate binds iron, zinc, and calcium into insoluble complexes that pass straight through the gut unabsorbed. The real deficit isn't intake; it's absorption. The solution is a powder that carries an enzyme capable of dismantling the phytate trap during digestion, releasing the minerals already present in the meal. The formulation is engineered to protect that enzyme through hot food mixing so it arrives in the stomach intact and active. The powder doesn't deliver nutrients. It unlocks the ones already on the plate.

Value to the Client

The output is a complete formulation with exact ingredients, amounts per scoop, processing method, stability notes, and supply chain risk flags, ready to take into development. Rather than competing with existing supplements on label claims, it offers a fundamentally different proposition: a meal enhancer that makes ordinary food work harder, with built-in pass/fail criteria for enzyme survival, phytate reduction, and child acceptance.

“

We've worked out a final formula with one of the solutions… how exciting. Moreover, we've managed to structure it in a way that removes the need for a testing phase in terms of new methods, which feels like a big step forward.
Ruth Harris

Goodness Pots, UK Children's Nutrition

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